MODELING THE LOCAL VISCOELASTIC BEHAVIOR OF LIVING CELLS UNDER NANOINDENTATION TESTS

Authors

  • THIAGO ANDRÉ CARNIEL UNIVERSIDADE FEDERAL DE SANTA CATARINA
  • EDUARDO ALBERTO FANCELLO UNIVERSIDADE FEDERAL DE SANTA CATARINA

Keywords:

LIVING CELLS, VISCOELASTICITY, CONSTITUTIVE MODEL, AFM NANOINDENTATION, MULTISCALE.

Abstract

AIMING MULTISCALE NUMERICAL INVESTIGATIONS OF FIBROUS CONNECTIVE TISSUES, THE PRESENT WORK PROPOSES A FINITE STRAIN VISCOELASTIC MODEL SUITABLE TO REPRESENT THE LOCAL MECHANICAL RESPONSE OF LIVING CELLS IN CONJUNCTION WITH FINITE ELEMENT SIMULATIONS OF NANOINDENTATION TESTS. THE MATERIAL MODEL IS FORMULATED IN A THERMODYNAMICALLY CONSISTENT FRAMEWORK BASED ON A VARIATIONAL CONSTITUTIVE APPROACH. AS A CASE OF STUDY, A NUMERICAL INVESTIGATION OF THE LOCAL COMPRESSIBLE RESPONSE OF FIBROBLAST CELLS IS ADDRESSED. MOREOVER, A SET OF CYCLIC, STRESS RELAXATION AND CREEP EXPERIMENTS ARE SIMULATED IN ORDER TO INVESTIGATE THE CAPABILITY OF THE MODEL TO PREDICT RATE DEPENDENCE OF CELLS, SHOWING SOUND AGREEMENT WITH EXPERIMENTAL DATA. THE PROPOSED MODEL MAY BE USED AS A SUITABLE TOOL FOR A BETTER UNDERSTANDING OF STIFFNESS AND ENERGETIC DISSIPATION OF CELLS.

Author Biographies

THIAGO ANDRÉ CARNIEL, UNIVERSIDADE FEDERAL DE SANTA CATARINA

THIAGO A. CARNIEL IS A PH.D. STUDENT AT THE PROGRAM OF POST GRADUATION IN MECHANICAL ENGINEERING OF THE UNIVERSIDADE FEDERAL DE SANTA CATARINA, BRAZIL.

EDUARDO ALBERTO FANCELLO, UNIVERSIDADE FEDERAL DE SANTA CATARINA

EDUARDO A. FANCELLO IS A FULL PROFESSOR AT THE MECHANICAL ENGINEERING DEPARTMENT OF THE UNIVERSIDADE FEDERAL DE SANTA CATARINA, BRAZIL.

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Published

2017-03-15

Issue

Vol. 14 No. 05 (2017)

Section

Articles

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